P-38: Protective Effects of Dorema Aucheri (Bilhar) Against Lead Acetate-Induced Reproductive Toxicity in Male Rats

most serious problem that leads to reproductive system failure in both human and animals. Present study was carried out to investigate whether hydroalcholic extract of Dorema aucheri leaves could protect the male rats against lead-induced reproductive toxicity. Materials and Methods: Adult wistar rats were treated with 0.1% lead acetate in drinking water with or without 100, 200 and 400 mg/kg Dorema aucheri extract via gavage for 70 days. Results: Lead acetate treatment resulted in significant (p<0.05) reductions in weight of testis, seminiferous tubules diameter, germinal epithelium height, epididymal sperm count and serum level of testosterone. However, no significant changes were observed in selected reproductive parameters in lead exposed rats treated with 100 and 200 mg/kg but not 400 mg/kg of Dorema aucheri extract. Conclusion: The results indicate hydroalcholic extract of Dorema aucheri leaves have a potential to restore the suppressed reproduction associated with lead exposure and prevented lead-induced reproductive toxicity in male Wistar rats.